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Preliminary program HPIG 2018 conference


Program at a glance:

(click on picture for pdf version)

The conference will start from 15:00 on July 4, and will finish lunchtime on July 7.

(disclaimer: the program may still be altered. Please contact the conference secretariat (Marian Jorgensen) if you have any queries or comments)



Wednesday 4 July – 12:00

Registration open, poster setup

OPENING SESSION (15:00-18:00)

Chair: Eliette Touati, France & Mario D’Elios, Italy

15:00 Leif Percival Andersen, Denmark Welcome
15:15 Richard Peek, USA Microbial carcinogens and the host immune response within the context of gastric cancer
15:45 Ichizo Kobayashi, Japan Base-excising Restriction Enzymes (HP-19)
16:15 BREAK
16:30 Zhang Jianzhong, China Gastric cancer and Helicobacter pylori infection in China
17:00 Discussion Panel:
Richard Peek, USA
Zhang Jianzhong, China
Celso Reis, Portugal
Gastric cancer and Helicobacter pylori - Facts and fictions

18:00 - DINNER


Contact Richard Ferrero or Steffen Backert. Remember to bring soccer clothes.




Chair: Karen Robinson, UK & Phil Sutton, Australia

08:30 Phil Sutton, Australia State of the art: A brief update and a new approach to vaccinating against Helicobacter pylori
HP-11 Hanna Gebreegziabher, Sweden Lactobacilli reduce production of pro-inflammatory cytokines TNF and IL-6 in Helicobacter pylori infected macrophages
HP-24 Anne Müller, Switzerland Helicobacter pylori infection induces neuropilin Tbet+ RORγt+ regulatory T-cells that accumulate in the lung and suppress allergen-specific immune responses in a VacA dependent manner
HP-41 E. Ogbodo, UK In vivo investigation of immunoregulatory properties of Helicobacter pylori infection
HP-43 Semper Raphaela, Germany Helicobacter pylori exploits Nlrc4 inflammasome to dampen host defences

10:00 - BREAK


Chair: Dionyssios Sgouras, Greece & Richard Peek, USA

10:30 Celso Reis, Portugal State of the art: Gastric cancer: overview, clinical implications and roles of glycosylation
HP-01 Maja Elling Christensen, Denmark The role of microbial pathogenesis in genome instability of human host: deregulation of DNA repair and mitochondrial bioenergetics
HP-06 Eliette Touati, France Downregulation of USF1 transcription factors impacts p53 during Helicobacter pylori infection and exacerbates gastric carcinogenesis
HP-28 Eleftherios Kontizas, Greece Impact of Helicobacter pylori infection on DNA damage repair mechanisms - A transcriptome analysis
HP-39 Rie Nordestgaard, Denmark Carcinogenic Helicobacter pylori strains identified by whole genome sequencing

12:00 - LUNCH

POSTER ROUNDS 1 and 2 (12:45 - 14:00)

POSTER ROUND 1, CHAIR: Caroline Gren, Denmark & Ming Chen, Denmark

HP-03 Desirazu N Rao, India Epigenetic regulation of gene expression by DNA methylation in Helicobacter pylori
HP-05 Chloë De Witte, Belgium Antimicrobial susceptibility pattern of Helicobacter suis isolates from pigs and macaques
HP-14 Markus Gerhard, Germany PYLOTUM: A reference laboratory for upper GI cancer
HP-16 Weronika Gonciarz, Poland Possible role of IL-33 in the gastric barrier homeostasis during Helicobacter pylori infection
HP-49 Amanda E. Rossiter, UK Polymicrobial interactions between Helicobacter pylori, Prevotella spp., Veillonella spp. and Actinomyces spp. and its implications in gastric carcinogenesis

POSTER ROUND 2, CHAIR: Lene Rasmussen, Denmark & Malene Spiegelhauer, Denmark

HP-22 Aileen Harrer, Germany Overexpression of serine protease HtrA in Helicobacter pylori enhances disruption of adherens junctions, paracellular transmigration of the bacteria and type IV secretion of CagA
HP-21 Steffen Backert, Germany Numbers behind the infection: quantification of secreted serine protease HtrA by Helicobacter pylori
HP-26 Ioannis Karayiannis, Greece Matrix metalloproteinase-3 (MMP-3/stromelysin-1) expression in the gastric tissue of C57BL/6 mice infected with Helicobacter pylori
HP-34 Sara K. Lindén, Sweden Building a library of 100 human gastric samples to use to delineate the role of genotype versus infection related glycan changes on Helicobacter pylori behavior
HP-36 Kaisa Thorell, Sweden Functional inference from a worldwide collection of H. pylori genomes

SESSION 3 (14:00-15:30): CagA AND T4SS

Chair: Christine Josenhans, Germany & Thomas Borén, Sweden

14:00 Laurent Terradot, France State of the art: Structural and biochemical characterization of cagT4SS pilus protein-protein interactions (HP-33)
HP-07 Emma Skoog, USA Helicobacter pylori colonization and type IV secretion system function are modulated by concurrent infection and the host immune response
HP-20 Steffen Backert, Germany A novel basolateral type IV secretion model for the CagA oncoprotein of Helicobacter pylori
HP-13 Youssef Hamway, Germany Investigating the structural and evolutionary basis of Helicobacter pylori adhesin HopQ binding to human CEACAMs

15:30 - BREAK


CHAIR: Christine Josenhans, Germany & Thomas Borén, Sweden

HopQ and interactions
Thomas Borén, Sweden The scene for the discussion
Rainer Haas, Germany The HopQ field and current hot-spots. Monomerization vs dimerisation of the ligands

Steffen Backert, Germany
Laurent Terradot, France
Rainer Haas, Germany
Emma Skoog, USA
Markus Gerhard, Germany
Han Remaut, Belgium

18:00 - DINNER


Busses leave for Kronborg




Chair: Sara Lindén, Sweden & Manuel Amieva, USA

08:30 Sara Lindén, Sweden State of the art: Adhesion, colonization and species differences
HP-25 Daniel Wilkinson, UK Investigating the within-patient genomic diversity of Helicobacter pylori populations from different niches of the human stomach
HP-29 Florent Ailloud, Germany Helicobacter pylori genome diversity within the human stomach: niche-specific adaptation, bacterial migration between gastric locations, and antibiotic-induced hard selective sweeps
HP-38 Malene Spiegelhauer, Denmark Gastric Microbiota
HP-44 Manuel Amieva, USA Helicobacter pylori infection of the stomach mucosa is organized into microscopic population islands that are critical for persistence and colonization resistance

10:00 - BREAK


Chair: Karen Krogfelt, Denmark & Freddy Haesebrouck, Belgium

10:30 Chloë De Witte, Belgium State of the art: Pathogenic significance of animal-associated, zoonotic gastric Helicobacter species, with emphasis on Helicobacter suis
HP-12 Eva Bauwens, Belgium Effect of a Helicobacter infection on the central nervous system
HP-15 Adrian Gajewski, Poland Deepening the harmful effect of Helicobacter pylori compounds on gastric barrier by 7ketocholesterol, acetylsalicylic acid and endogenous factors in the light of increased risk of coronary heart disease
HP-17 Médea Padra, Sweden Helicobacter suis binding to carbohydrates on gastric mucins and glycolipids occurs via two modes and infection with this pathogen alters host mucin glycosylation
HP-35 Sara Lindén, Sweden Helicobacter pylori Pediatric Strains from Patients with Non-ulcer Dyspepsia and Peptic Ulcer Disease Differ in their Binding Ability to Mucins

12:00 - LUNCH

POSTER ROUND 3 (12:45 - 14:00)

POSTER ROUND 3, CHAIR: Rie Nordestgaard, Denmark & Leif Percival Andersen, Denmark

HP-40 Karolina Rudnicka, Poland Antimicrobial and anti-adhesive activity of selected plant extracts against H. pylori in relation to their immunomodulatory properties towards innate immunity cells
HP-42 Raquel Mejías-Luque, Germany Activation of non-canonical NF-ĸB associated with LIGHT up-regulation is related to Helicobacter felis-induced pathology in MyD88-deficient mice
HP-45 Paula Díaz, Chile Helicobacter pylori infection reduces protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) activity to modulate survivin-associated cell proliferation in gastric cells
HP-47 Jody Winter, UK Roles of outer membrane vesicles in Helicobacter pylori stress survival
HP-48 Sungil Jang, South Korea Effect of immune response on variation of Helicobacter pylori cagA copy number


Chair: Anne Müller, Switzerland & Richard Ferrero, Australia

14:00 Christine Josenhans, Germany State of the art: Cag-PAI dependent and Cag-PAI independent interaction of H. pylori with the innate immune system
HP-02 Mario M. D’Elios, Italy HP1454 protein of Helicobacter pylori regulates T cell response by shaping T Cell receptor signaling
HP-18 Isabelle C. Arnold, Switzerland Eosinophils suppress Th1 responses and restrict H. pylori- induced gastrointestinal inflammation
HP-37 Harry Jenkins, UK Peripheral Cytokines as Biomarkers for Helicobacter pylori Infection and Disease Risk
HP-46 Michelle Chonwerawong, Australia Myeloid-specific NLRC5 plays a protective role against gastric B cell lymphomagenesis to chronic Helicobacter infection

15:30 - BREAK


Chair: Hilde De Reuse, France & Sebastian Suerbaum, Germany

16:00 Daniel Falush, UK State of the art: Repeated out-of-Africa expansions of Helicobacter pylori are driven by deleterious mutations (HP-27)
HP-23 Iratxe Estibariz, Germany Strain-specific regulation of genes by a highly conserved m5C-methyltransferase in the gastric pathogen H. pylori
HP-30 Alejandro Tejada Arranz, France Study of the Helicobacter pylori RNA degradosome, a major actor in post-transcriptional regulation
HP-32 Sumith Kumar, India N-4 cytosine DNA methylation epigenetically regulates gene expression and pathogenesis in Helicobacter pylori

18:00 - DINNER

19:30 - BUSINESS MEETING. Open for everyone. Room to be announced.





Chair: Jay Solnick, USA & OPEN

08:30 J. Pablo Radicella, France State of the art: Genetic and molecular transformation of Helicobacter pylori
HP-08 Prashant P. Damke, France The enigmatic ComFC proteins: clues on the possible cellular function from the studies on natural transformation of Helicobacter pylori
HP-09 J. Pablo Radicella, France Role of ComH in natural transformation of Helicobacter pylori
HP-31 Hilde de Reuse, France Morphological transformation of Helicobacter pylori induced by a small peptide of a type I toxin-antitoxin system

10:00 - BREAK


CHAIR: Sebastian Suerbaum, Germany, Freddy Haesebrouck, Belgium, Leif Percival Andersen, Denmark & Thomas Borén, Sweden

Karen Krogfelt, Denmark
Annemieke Smet, Belgium
Emma Skoog, USA
Kaisa Thorell, Sweden
Karolina Rudnicka, Poland
Raquel Mejías-Luque, Germany

Best overall presentation by a young scientist
4 best oral presentations by a young scientist
2 best poster presentations by a young scientist



Last updated: 29 June, 2018